About Proteasome subunit beta type-3
Proteasome subunit beta type-3 (PSMB3) is a protein
from Homo sapiens identified by UniProt accession
P49720, 205 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Proteasome subunit beta type-3 |
|---|
| UniProt accession | P49720 |
|---|
| Gene | PSMB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 205 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- neurodegenerative disease · score 0.38
- glioblastoma multiforme · score 0.28
- squamous cell lung carcinoma · score 0.28
- gastric adenocarcinoma · score 0.27
- lean body mass · score 0.22
- heel bone mineral density · score 0.19
- body height · score 0.18
- fat body mass · score 0.16
- FEV/FVC ratio · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49720-F1 | alphafold | PREDICTED | 97.29 | — |
Amino-acid sequence (205 residues)
MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV SGMGVIVHII EKDKITTRTL KARMD
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