About Proteasome subunit beta type-2
Proteasome subunit beta type-2 (PSMB2) is a protein
from Homo sapiens identified by UniProt accession
P49721, 201 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Proteasome subunit beta type-2 |
|---|
| UniProt accession | P49721 |
|---|
| Gene | PSMB2 |
|---|
| Organism | Homo sapiens |
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| Length | 201 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (57)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- endometrial cancer · score 0.29
- glioblastoma multiforme · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- gastric adenocarcinoma · score 0.27
- multiple myeloma · score 0.09
- sex hormone-binding globulin measurement · score 0.07
- ependymoma · score 0.07
- Paraganglioma · score 0.07
- anaplastic ependymoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49721-F1 | alphafold | PREDICTED | 96.69 | — |
Amino-acid sequence (201 residues)
MEYLIGIQGP DYVLVASDRV AASNIVQMKD DHDKMFKMSE KILLLCVGEA GDTVQFAEYI QKNVQLYKMR NGYELSPTAA ANFTRRNLAD CLRSRTPYHV NLLLAGYDEH EGPALYYMDY LAALAKAPFA AHGYGAFLTL SILDRYYTPT ISRERAVELL RKCLEELQKR FILNLPTFSV RIIDKNGIHD LDNISFPKQG S
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