About Cartilage oligomeric matrix protein
Cartilage oligomeric matrix protein (COMP) is a protein
from Homo sapiens identified by UniProt accession
P49747, 757 residues long.
MolForge cross-references it against 0 known binders and
524 disease associations.
Target properties
| Protein name | Cartilage oligomeric matrix protein |
|---|
| UniProt accession | P49747 |
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| Gene | COMP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 757 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (524)
Diseases linked to this target (Open Targets).
- pseudoachondroplasia · score 0.83
- multiple epiphyseal dysplasia type 1 · score 0.82
- carpal tunnel syndrome · score 0.49
- multiple epiphyseal dysplasia · score 0.44
- neurodegenerative disease · score 0.44
- multiple epiphyseal dysplasia, Beighton type · score 0.38
- Abnormality of the skeletal system · score 0.34
- Alzheimer disease · score 0.33
- Parkinson disease · score 0.33
- lysosomal storage disease · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49747-F1 | alphafold | PREDICTED | 88.14 | — |
Amino-acid sequence (757 residues)
MVPDTACVLL LTLAALGASG QGQSPLGSDL GPQMLRELQE TNAALQDVRE LLRQQVREIT FLKNTVMECD ACGMQQSVRT GLPSVRPLLH CAPGFCFPGV ACIQTESGAR CGPCPAGFTG NGSHCTDVNE CNAHPCFPRV RCINTSPGFR CEACPPGYSG PTHQGVGLAF AKANKQVCTD INECETGQHN CVPNSVCINT RGSFQCGPCQ PGFVGDQASG CQRRAQRFCP DGSPSECHEH ADCVLERDGS RSCVCAVGWA GNGILCGRDT DLDGFPDEKL RCPERQCRKD NCVTVPNSGQ EDVDRDGIGD ACDPDADGDG VPNEKDNCPL VRNPDQRNTD EDKWGDACDN CRSQKNDDQK DTDQDGRGDA CDDDIDGDRI RNQADNCPRV PNSDQKDSDG DGIGDACDNC PQKSNPDQAD VDHDFVGDAC DSDQDQDGDG HQDSRDNCPT VPNSAQEDSD HDGQGDACDD DDDNDGVPDS RDNCRLVPNP GQEDADRDGV GDVCQDDFDA DKVVDKIDVC PENAEVTLTD FRAFQTVVLD PEGDAQIDPN WVVLNQGREI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDYAGFI FGYQDSSSFY VVMWKQMEQT YWQANPFRAV AEPGIQLKAV KSSTGPGEQL RNALWHTGDT ESQVRLLWKD PRNVGWKDKK SYRWFLQHRP QVGYIRVRFY EGPELVADSN VVLDTTMRGG RLGVFCFSQE NIIWANLRYR CNDTIPEDYE THQLRQA
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