About Very long-chain acyl-CoA dehydrogenase, mitochondrial
Very long-chain acyl-CoA dehydrogenase, mitochondrial (ACADVL) is a protein
from Homo sapiens identified by UniProt accession
P49748, 655 residues long.
MolForge cross-references it against 0 known binders and
213 disease associations.
Target properties
| Protein name | Very long-chain acyl-CoA dehydrogenase, mitochondrial |
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| UniProt accession | P49748 |
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| Gene | ACADVL |
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| Organism | Homo sapiens |
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| Length | 655 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (213)
Diseases linked to this target (Open Targets).
- very long chain acyl-CoA dehydrogenase deficiency · score 0.87
- genetic disorder · score 0.53
- rhabdomyolysis · score 0.46
- Abnormal circulating enzyme concentration · score 0.42
- hypertrophic cardiomyopathy · score 0.38
- metabolic myopathy · score 0.37
- Abnormality of the musculature · score 0.36
- cardiac arrhythmia · score 0.34
- myopathy · score 0.33
- autism spectrum disorder · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49748-F1 | alphafold | PREDICTED | 90.25 | — |
Amino-acid sequence (655 residues)
MQAARMAASL GRQLLRLGGG SSRLTALLGQ PRPGPARRPY AGGAAQLALD KSDSHPSDAL TRKKPAKAES KSFAVGMFKG QLTTDQVFPY PSVLNEEQTQ FLKELVEPVS RFFEEVNDPA KNDALEMVEE TTWQGLKELG AFGLQVPSEL GGVGLCNTQY ARLVEIVGMH DLGVGITLGA HQSIGFKGIL LFGTKAQKEK YLPKLASGET VAAFCLTEPS SGSDAASIRT SAVPSPCGKY YTLNGSKLWI SNGGLADIFT VFAKTPVTDP ATGAVKEKIT AFVVERGFGG ITHGPPEKKM GIKASNTAEV FFDGVRVPSE NVLGEVGSGF KVAMHILNNG RFGMAAALAG TMRGIIAKAV DHATNRTQFG EKIHNFGLIQ EKLARMVMLQ YVTESMAYMV SANMDQGATD FQIEAAISKI FGSEAAWKVT DECIQIMGGM GFMKEPGVER VLRDLRIFRI FEGTNDILRL FVALQGCMDK GKELSGLGSA LKNPFGNAGL LLGEAGKQLR RRAGLGSGLS LSGLVHPELS RSGELAVRAL EQFATVVEAK LIKHKKGIVN EQFLLQRLAD GAIDLYAMVV VLSRASRSLS EGHPTAQHEK MLCDTWCIEA AARIREGMAA LQSDPWQQEL YRNFKSISKA LVERGGVVTS NPLGF
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