YLP motif-containing protein 1 (YLPM1)

About YLP motif-containing protein 1

YLP motif-containing protein 1 (YLPM1) is a protein from Homo sapiens identified by UniProt accession P49750, 2146 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	YLP motif-containing protein 1
UniProt accession	P49750
Gene	YLPM1
Organism	Homo sapiens
Length	2146 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
total cholesterol measurement · score 0.29
platelet count · score 0.28
FEV/FVC ratio · score 0.26
unipolar depression · score 0.24
body fat percentage · score 0.22
high density lipoprotein cholesterol measurement · score 0.22
neuroticism measurement · score 0.22
low density lipoprotein cholesterol measurement · score 0.21
appendicular lean mass · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49750-F1	alphafold	PREDICTED	43.24	—

Amino-acid sequence (2146 residues)

MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF MSFREQHLAQ LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW QPPPPPMPPP PGPALSYQKQ QQYKHQMLHH QRDGPPGLVP MELESPPESP PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS QPYLPPAQPS PSQSPPSQSY LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS KSQLLAPPPP SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE PPLPPPNEEV PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF QYQGIMQKHT QLQQILQQYQ QIIQPPPHIQ TMSVDMQLRH YEMQQQQFQH LYQEWEREFQ LWEEQLHSYP HKDQLQEYEK QWKTWQGHMK ATQSYLQEKV NSFQNMKNQY MGNMSMPPPF VPYSQMPPPL PTMPPPVLPP SLPPPVMPPA LPATVPPPGM PPPVMPPSLP TSVPPPGMPP SLSSAGPPPV LPPPSLSSAG PPPVLPPPSL SSTAPPPVMP LPPLSSATPP PGIPPPGVPQ GIPPQLTAAP VPPASSSQSS QVPEKPRPAL LPTPVSFGSA PPTTYHPPLQ SAGPSEQVNS KAPLSKSALP YSSFSSDQGL GESSAAPSQP ITAVKDMPVR SGGLLPDPPR SSYLESPRGP RFDGPRRFED LGSRCEGPRP KGPRFEGNRP DGPRPRYEGH PAEGTKSKWG MIPRGPASQF YITPSTSLSP RQSGPQWKGP KPAFGQQHQQ QPKSQAEPLS GNKEPLADTS SNQQKNFKMQ SAAFSIAADV KDVKAAQSNE NLSDSQQEPP KSEVSEGPVE PSNWDQNVQS METQIDKAQA VTQPVPLANK PVPAQSTFPS KTGGMEGGTA VATSSLTADN DFKPVGIGLP HSENNQDKGL PRPDNRDNRL EGNRGNSSSY RGPGQSRMED TRDKGLVNRG RGQAISRGPG LVKQEDFRDK MMGRREDSRE KMNRGEGSRD RGLVRPGSSR EKVPGGLQGS QDRGAAGSRE RGPPRRAGSQ ERGPLRRAGS RERIPPRRAG SRERGPPRGP GSRERGLGRS DFGRDRGPFR PEPGDGGEKM YPYHRDEPPR APWNHGEERG HEEFPLDGRN APMERERLDD WDRERYWREC ERDYQDDTLE LYNREDRFSA PPSRSHDGDR RGPWWDDWER DQDMDEDYNR EMERDMDRDV DRISRPMDMY DRSLDNEWDR DYGRPLDEQE SQFRERDIPS LPPLPPLPPL PPLDRYRDDR WREERNREHG YDRDFRDRGE LRIREYPERG DTWREKRDYV PDRMDWERER LSDRWYPSDV DRHSPMAEHM PSSHHSSEMM GSDASLDSDQ GLGGVMVLSQ RQHEIILKAA QELKMLREQK EQLQKMKDFG SEPQMADHLP PQESRLQNTS SRPGMYPPPG SYRPPPPMGK PPGSIVRPSA PPARSSVPVT RPPVPIPPPP PPPPLPPPPP VIKPQTSAVE QERWDEDSFY GLWDTNDEQG LNSEFKSETA AIPSAPVLPP PPVHSSIPPP GPVPMGMPPM SKPPPVQQTV DYGHGRDIST NKVEQIPYGE RITLRPDPLP ERSTFETEHA GQRDRYDRER DREPYFDRQS NVIADHRDFK RDRETHRDRD RDRGVIDYDR DRFDRERRPR DDRAQSYRDK KDHSSSRRGG FDRPSYDRKS DRPVYEGPSM FGGERRTYPE ERMPLPAPSL SHQPPPAPRV EKKPESKNVD DILKPPGRES RPERIVVIMR GLPGSGKTHV AKLIRDKEVE FGGPAPRVLS LDDYFITEVE KEEKDPDSGK KVKKKVMEYE YEAEMEETYR TSMFKTFKKT LDDGFFPFII LDAINDRVRH FDQFWSAAKT KGFEVYLAEM SADNQTCGKR NIHGRKLKEI NKMADHWETA PRHMMRLDIR SLLQDAAIEE VEMEDFDANI EEQKEEKKDA EEEESELGYI PKSKWEMDTS EAKLDKLDGL RTGTKRKRDW EAIASRMEDY LQLPDDYDTR ASEPGKKRVR WADLEEKKDA DRKRAIGFVV GQTDWEKITD ESGHLAEKAL NRTKYI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards