About Acyl-coenzyme A thioesterase 2, mitochondrial
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2) is a protein
from Homo sapiens identified by UniProt accession
P49753, 483 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Acyl-coenzyme A thioesterase 2, mitochondrial |
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| UniProt accession | P49753 |
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| Gene | ACOT2 |
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| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.22
- creatinine measurement · score 0.15
- glomerular filtration rate · score 0.10
- acute myeloid leukemia · score 0.07
- Blackfan-Diamond anemia · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- hemoglobin D disease · score 0.06
- Heinz body anemia · score 0.05
- delta-beta-thalassemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49753-F1 | alphafold | PREDICTED | 89.14 | — |
Amino-acid sequence (483 residues)
MSNKLLSPHP HSVVLRSEFK MASSPAVLRA SRLYQWSLKS SAQFLGSPQL RQVGQIIRVP ARMAATLILE PAGRCCWDEP VRIAVRGLAP EQPVTLRASL RDEKGALFQA HARYRADTLG ELDLERAPAL GGSFAGLEPM GLLWALEPEK PLVRLVKRDV RTPLAVELEV LDGHDPDPGR LLCQTRHERY FLPPGVRREP VRVGRVRGTL FLPPEPGPFP GIVDMFGTGG GLLEYRASLL AGKGFAVMAL AYYNYEDLPK TMETLHLEYF EEAMNYLLSH PEVKGPGVGL LGISKGGELC LSMASFLKGI TAAVVINGSV ANVGGTLHYK GETLPPVGVN RNRIKVTKDG YADIVDVLNS PLEGPDQKSF IPVERAESTF LFLVGQDDHN WKSEFYANEA CKRLQAHGRR KPQIICYPET GHYIEPPYFP LCRASLHALV GSPIIWGGEP RAHAMAQVDA WKQLQTFFHK HLGGHEGTIP SKV
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