About Protein numb homolog
Protein numb homolog (NUMB) is a protein
from Homo sapiens identified by UniProt accession
P49757, 651 residues long.
MolForge cross-references it against 0 known binders and
202 disease associations.
Target properties
| Protein name | Protein numb homolog |
|---|
| UniProt accession | P49757 |
|---|
| Gene | NUMB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 651 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (202)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.24
- hemoglobin measurement · score 0.24
- breast adenocarcinoma · score 0.22
- multisite chronic pain · score 0.21
- head and neck squamous cell carcinoma · score 0.21
- creatinine measurement · score 0.21
- endometrial cancer · score 0.20
- hypertension · score 0.19
- white matter hyperintensity measurement · score 0.19
- ovarian cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49757-F1 | alphafold | PREDICTED | 59.48 | — |
Amino-acid sequence (651 residues)
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L
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