About Dual specificity protein kinase CLK1
Dual specificity protein kinase CLK1 (CLK1) is a protein
from Homo sapiens identified by UniProt accession
P49759, 484 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Dual specificity protein kinase CLK1 |
|---|
| UniProt accession | P49759 |
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| Gene | CLK1 |
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| Organism | Homo sapiens |
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| Length | 484 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (106)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- cancer · score 0.11
- Red cell distribution width · score 0.05
- aceruloplasminemia · score 0.04
- episodic ataxia type 1 · score 0.04
- retinitis pigmentosa and erythrocytic microcytosis · score 0.04
- Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome · score 0.03
- pseudohypoparathyroidism type 2 · score 0.03
- Paroxysmal exertion-induced dyskinesia · score 0.03
- Glutathione synthetase deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49759-F1 | alphafold | PREDICTED | 79.06 | — |
Amino-acid sequence (484 residues)
MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD EHSSAGRYVS RRCKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL KKSI
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