About Dual specificity protein kinase CLK2
Dual specificity protein kinase CLK2 (CLK2) is a protein
from Homo sapiens identified by UniProt accession
P49760, 499 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Dual specificity protein kinase CLK2 |
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| UniProt accession | P49760 |
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| Gene | CLK2 |
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| Organism | Homo sapiens |
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| Length | 499 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (31)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.44
- multiple sclerosis · score 0.44
- neurodegenerative disease · score 0.44
- lysosomal storage disease · score 0.44
- Parkinson disease · score 0.44
- neuroinflammatory disorder · score 0.39
- leukocyte count · score 0.15
- Red cell distribution width · score 0.12
- Crohn's disease · score 0.09
- HbA1c measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49760-F1 | alphafold | PREDICTED | 77.48 | — |
Amino-acid sequence (499 residues)
MPHPRRYHSS ERGSRGSYRE HYRSRKHKRR RSRSWSSSSD RTRRRRREDS YHVRSRSSYD DRSSDRRVYD RRYCGSYRRN DYSRDRGDAY YDTDYRHSYE YQRENSSYRS QRSSRRKHRR RRRRSRTFSR SSSQHSSRRA KSVEDDAEGH LIYHVGDWLQ ERYEIVSTLG EGTFGRVVQC VDHRRGGARV ALKIIKNVEK YKEAARLEIN VLEKINEKDP DNKNLCVQMF DWFDYHGHMC ISFELLGLST FDFLKDNNYL PYPIHQVRHM AFQLCQAVKF LHDNKLTHTD LKPENILFVN SDYELTYNLE KKRDERSVKS TAVRVVDFGS ATFDHEHHST IVSTRHYRAP EVILELGWSQ PCDVWSIGCI IFEYYVGFTL FQTHDNREHL AMMERILGPI PSRMIRKTRK QKYFYRGRLD WDENTSAGRY VRENCKPLRR YLTSEAEEHH QLFDLIESML EYEPAKRLTL GEALQHPFFA RLRAEPPNKL WDSSRDISR
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