About Dual specificity protein kinase CLK3
Dual specificity protein kinase CLK3 (CLK3) is a protein
from Homo sapiens identified by UniProt accession
P49761, 490 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Dual specificity protein kinase CLK3 |
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| UniProt accession | P49761 |
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| Gene | CLK3 |
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| Organism | Homo sapiens |
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| Length | 490 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Parkinson disease · score 0.41
- lysosomal storage disease · score 0.41
- multiple sclerosis · score 0.41
- Alzheimer disease · score 0.41
- caffeine metabolite measurement · score 0.08
- cholangiocarcinoma · score 0.08
- hepatocellular carcinoma · score 0.08
- mean platelet volume · score 0.07
- urinary bladder carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49761-F1 | alphafold | PREDICTED | 79.03 | — |
Amino-acid sequence (490 residues)
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRLPYQRR YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP YRTRKHAHHC HKRRTRSCSS ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD GRYVKENCKP LKSYMLQDSL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER SFHTSRNPSR
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