About Placenta growth factor
Placenta growth factor (PGF) is a protein
from Homo sapiens identified by UniProt accession
P49763, 221 residues long.
MolForge cross-references it against 0 known binders and
541 disease associations.
Target properties
| Protein name | Placenta growth factor |
|---|
| UniProt accession | P49763 |
|---|
| Gene | PGF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 221 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (541)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.60
- diabetic macular edema · score 0.60
- wet macular degeneration · score 0.58
- macular retinal edema · score 0.56
- retinal vein occlusion · score 0.56
- diabetic retinopathy · score 0.54
- macular degeneration · score 0.53
- metastatic colorectal cancer · score 0.49
- neoplasm · score 0.42
- proliferative diabetic retinopathy · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49763-F1 | alphafold | PREDICTED | 70.60 | — |
Amino-acid sequence (221 residues)
MPVMRLFPCF LQLLAGLALP AVPPQQWALS AGNGSSEVEV VPFQEVWGRS YCRALERLVD VVSEYPSEVE HMFSPSCVSL LRCTGCCGDE NLHCVPVETA NVTMQLLKIR SGDRPSYVEL TFSQHVRCEC RHSPGRQSPD MPGDFRADAP SFLPPRRSLP MLFRMEWGCA LTGSQSAVWP SSPVPEEIPR MHPGRNGKKQ QRKPLREKMK PERCGDAVPR R
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