About Vascular endothelial growth factor B
Vascular endothelial growth factor B (VEGFB) is a protein
from Homo sapiens identified by UniProt accession
P49765, 207 residues long.
MolForge cross-references it against 0 known binders and
422 disease associations.
Target properties
| Protein name | Vascular endothelial growth factor B |
|---|
| UniProt accession | P49765 |
|---|
| Gene | VEGFB |
|---|
| Organism | Homo sapiens |
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| Length | 207 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (422)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.49
- diabetic macular edema · score 0.44
- proliferative diabetic retinopathy · score 0.40
- retinal detachment · score 0.37
- pathological myopia · score 0.26
- cutaneous melanoma · score 0.20
- apolipoprotein A 1 measurement · score 0.19
- HbA1c measurement · score 0.18
- triglyceride measurement · score 0.17
- mean corpuscular volume · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49765-F1 | alphafold | PREDICTED | 73.49 | — |
Amino-acid sequence (207 residues)
MSPLLRRLLL AALLQLAPAQ APVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP STTSALTPGP AAAAADAAAS SVAKGGA
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