Vascular endothelial growth factor C (VEGFC)

About Vascular endothelial growth factor C

Vascular endothelial growth factor C (VEGFC) is a protein from Homo sapiens identified by UniProt accession P49767, 419 residues long. MolForge cross-references it against 0 known binders and 593 disease associations.

Target properties

Protein name	Vascular endothelial growth factor C
UniProt accession	P49767
Gene	VEGFC
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (593)

Diseases linked to this target (Open Targets).

Milroy disease · score 0.61
age-related macular degeneration · score 0.49
diabetic macular edema · score 0.44
serum albumin measurement · score 0.43
hematocrit · score 0.41
FEV/FVC ratio · score 0.41
proliferative diabetic retinopathy · score 0.40
retinal detachment · score 0.37
appendicular lean mass · score 0.36
neurodegenerative disease · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49767-F1	alphafold	PREDICTED	73.20	—

Amino-acid sequence (419 residues)

MHLLGFFSVA CSLLAAALLP GPREAPAAAA AFESGLDLSD AEPDAGEATA YASKDLEEQL RSVSSVDELM TVLYPEYWKM YKCQLRKGGW QHNREQANLN SRTEETIKFA AAHYNTEILK SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRRSLP ATLPQCQAAN KTCPTNYMWN NHICRCLAQE DFMFSSDAGD DSTDGFHDIC GPNKELDEET CQCVCRAGLR PASCGPHKEL DRNSCQCVCK NKLFPSQCGA NREFDENTCQ CVCKRTCPRN QPLNPGKCAC ECTESPQKCL LKGKKFHHQT CSCYRRPCTN RQKACEPGFS YSEEVCRCVP SYWKRPQMS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards