Presenilin-1 (PSEN1)

About Presenilin-1

Presenilin-1 (PSEN1) is a protein from Homo sapiens identified by UniProt accession P49768, 467 residues long. MolForge cross-references it against 0 known binders and 504 disease associations.

Target properties

Protein name	Presenilin-1
UniProt accession	P49768
Gene	PSEN1
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (504)

Diseases linked to this target (Open Targets).

Alzheimer disease 3 · score 0.84
acne inversa, familial, 3 · score 0.72
Pick disease · score 0.72
semantic dementia · score 0.67
dilated cardiomyopathy 1U · score 0.63
Alzheimer disease · score 0.58
early-onset autosomal dominant Alzheimer disease · score 0.56
frontotemporal dementia · score 0.56
dilated cardiomyopathy · score 0.51
dementia · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49768-F1	alphafold	PREDICTED	72.14	—

Amino-acid sequence (467 residues)

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards