About Fms-related tyrosine kinase 3 ligand
Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein
from Homo sapiens identified by UniProt accession
P49771, 235 residues long.
MolForge cross-references it against 0 known binders and
486 disease associations.
Target properties
| Protein name | Fms-related tyrosine kinase 3 ligand |
|---|
| UniProt accession | P49771 |
|---|
| Gene | FLT3LG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 235 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (486)
Diseases linked to this target (Open Targets).
- cancer · score 0.51
- monocyte count · score 0.38
- neurodegenerative disease · score 0.37
- monocyte percentage of leukocytes · score 0.26
- total blood protein measurement · score 0.25
- thyroid gland adenocarcinoma · score 0.23
- neoplasm · score 0.12
- Rheumatoid arthritis · score 0.09
- blood protein measurement · score 0.08
- isolated agammaglobulinemia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49771-F1 | alphafold | PREDICTED | 81.30 | — |
Amino-acid sequence (235 residues)
MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT APQPPLLLLL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH
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