Adenosine 5'-monophosphoramidase HINT1 (HINT1)

About Adenosine 5'-monophosphoramidase HINT1

Adenosine 5'-monophosphoramidase HINT1 (HINT1) is a protein from Homo sapiens identified by UniProt accession P49773, 126 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.

Target properties

Protein name	Adenosine 5'-monophosphoramidase HINT1
UniProt accession	P49773
Gene	HINT1
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (211)

Diseases linked to this target (Open Targets).

Autosomal recessive axonal neuropathy with neuromyotonia · score 0.80
Gamstorp-Wohlfart syndrome · score 0.73
genetic disorder · score 0.48
Charcot-Marie-Tooth disease · score 0.41
peripheral neuropathy · score 0.41
neurodegenerative disease · score 0.34
Sensory axonal neuropathy · score 0.26
body mass index · score 0.24
eosinophil count · score 0.19
C-reactive protein measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49773-F1	alphafold	PREDICTED	96.17	—

Amino-acid sequence (126 residues)

MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards