Retinoic acid receptor responder protein 1 (RARRES1)

About Retinoic acid receptor responder protein 1

Retinoic acid receptor responder protein 1 (RARRES1) is a protein from Homo sapiens identified by UniProt accession P49788, 294 residues long. MolForge cross-references it against 0 known binders and 175 disease associations.

Target properties

Protein name	Retinoic acid receptor responder protein 1
UniProt accession	P49788
Gene	RARRES1
Organism	Homo sapiens
Length	294 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (175)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.32
diastolic blood pressure · score 0.14
blood protein measurement · score 0.14
insomnia measurement · score 0.10
neoplasm · score 0.10
renal cell carcinoma · score 0.09
triple-negative breast cancer · score 0.09
cancer · score 0.08
hypertension · score 0.08
hepatocellular carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49788-F1	alphafold	PREDICTED	78.30	—

Amino-acid sequence (294 residues)

MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ DAGVPRRLLQ QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK VHVVFSTERY NPESLLQEGE GRLGKCSARV FFKNQKPRPT INVTCTRLIE KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN HGHIDPSLRL IWDLAFLGSS YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH ELSTQEIIPC RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards