Bis(5'-adenosyl)-triphosphatase (FHIT)

About Bis(5'-adenosyl)-triphosphatase

Bis(5'-adenosyl)-triphosphatase (FHIT) is a protein from Homo sapiens identified by UniProt accession P49789, 147 residues long. MolForge cross-references it against 0 known binders and 475 disease associations.

Target properties

Protein name	Bis(5'-adenosyl)-triphosphatase
UniProt accession	P49789
Gene	FHIT
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (475)

Diseases linked to this target (Open Targets).

body mass index · score 0.48
body fat percentage · score 0.44
lean body mass · score 0.44
unipolar depression · score 0.43
physical activity measurement · score 0.42
gut microbiome measurement · score 0.41
smoking behavior · score 0.41
fat body mass · score 0.41
body weight · score 0.41
PHF-tau measurement · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49789-F1	alphafold	PREDICTED	95.24	—

Amino-acid sequence (147 residues)

MSFRFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLVCP LRPVERFHDL RPDEVADLFQ TTQRVGTVVE KHFHGTSLTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH DKEDFPASWR SEEEMAAEAA ALRVYFQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards