About Glycogen synthase kinase-3 alpha
Glycogen synthase kinase-3 alpha (GSK3A) is a protein
from Homo sapiens identified by UniProt accession
P49840, 483 residues long.
MolForge cross-references it against 0 known binders and
334 disease associations.
Target properties
| Protein name | Glycogen synthase kinase-3 alpha |
|---|
| UniProt accession | P49840 |
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| Gene | GSK3A |
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| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (334)
Diseases linked to this target (Open Targets).
- bipolar disorder · score 0.61
- depressive disorder · score 0.58
- bipolar I disorder · score 0.58
- major depressive disorder · score 0.53
- schizophrenia · score 0.47
- COVID-19 · score 0.37
- Cognitive impairment · score 0.37
- severe acute respiratory syndrome · score 0.37
- unipolar depression · score 0.37
- HIV infection · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49840-F1 | alphafold | PREDICTED | 78.88 | — |
Amino-acid sequence (483 residues)
MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT NSS
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