About Winged helix repair factor 1
Winged helix repair factor 1 (WHR1) is a protein
from Homo sapiens identified by UniProt accession
P49842, 254 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Winged helix repair factor 1 |
|---|
| UniProt accession | P49842 |
|---|
| Gene | WHR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 254 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- skin squamous cell carcinoma · score 0.26
- cutaneous melanoma · score 0.26
- monocyte count · score 0.13
- lymphocyte count · score 0.13
- blood protein measurement · score 0.13
- gp41 C34 peptide, HIV measurement · score 0.08
- C3a anaphylatoxin des arginine measurement · score 0.07
- psoriatic arthritis · score 0.06
- von Willebrand factor measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49842-F1 | alphafold | PREDICTED | 87.41 | — |
Amino-acid sequence (254 residues)
MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV SELMQLFPRG LFEDALPPIV LRSQVYSLVP DRTVADRQLK ELQEQGEIRI VQLGFDLDAH GIIFTEDYRT RVLKACDGRP YAGAVQKFLA SVLPACGDLS FQQDQMTQTF GFRDSEITHL VNAGVLTVRD AGSWWLAVPG AGRFIKYFVK GRQAVLSMVR KAKYRELLLS ELLGRRAPVV VRLGLTYHVH DLIGAQLVDC ISTTSGTLLR LPET
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