About Granzyme K
Granzyme K (GZMK) is a protein
from Homo sapiens identified by UniProt accession
P49863, 264 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | Granzyme K |
|---|
| UniProt accession | P49863 |
|---|
| Gene | GZMK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 264 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (158)
Diseases linked to this target (Open Targets).
- endothelial cell-specific molecule 1 measurement · score 0.29
- PHF-tau measurement · score 0.09
- breast milk measurement · score 0.09
- Rheumatoid arthritis · score 0.08
- psoriasis · score 0.08
- FEV/FVC ratio · score 0.07
- Sepsis · score 0.06
- neoplasm · score 0.06
- stroke · score 0.05
- Arterial occlusion · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49863-F1 | alphafold | PREDICTED | 85.43 | — |
Amino-acid sequence (264 residues)
MTKFSSFSLF FLIVGAYMTH VCFNMEIIGG KEVSPHSRPF MASIQYGGHH VCGGVLIDPQ WVLTAAHCQY RFTKGQSPTV VLGAHSLSKN EASKQTLEIK KFIPFSRVTS DPQSNDIMLV KLQTAAKLNK HVKMLHIRSK TSLRSGTKCK VTGWGATDPD SLRPSDTLRE VTVTVLSRKL CNSQSYYNGD PFITKDMVCA GDAKGQKDSC KGDSGGPLIC KGVFHAIVSG GHECGVATKP GIYTLLTKKY QTWIKSNLVP PHTN
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