About Type I iodothyronine deiodinase
Type I iodothyronine deiodinase (DIO1) is a protein
from Homo sapiens identified by UniProt accession
P49895, 249 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Type I iodothyronine deiodinase |
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| UniProt accession | P49895 |
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| Gene | DIO1 |
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| Organism | Homo sapiens |
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| Length | 249 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (83)
Diseases linked to this target (Open Targets).
- thyroid hormone metabolism, abnormal, 2 · score 0.61
- hyperthyroidism · score 0.46
- Graves ophthalmopathy · score 0.43
- Abnormality of the thyroid gland · score 0.37
- thyroxine measurement · score 0.36
- hormone measurement · score 0.33
- Thyrotoxicosis · score 0.26
- Graves disease · score 0.26
- gut microbiome measurement · score 0.18
- cutaneous melanoma · score 0.16
Amino-acid sequence (249 residues)
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV RAVLEKLHS
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