About Cytosolic purine 5'-nucleotidase
Cytosolic purine 5'-nucleotidase (NT5C2) is a protein
from Homo sapiens identified by UniProt accession
P49902, 561 residues long.
MolForge cross-references it against 0 known binders and
276 disease associations.
Target properties
| Protein name | Cytosolic purine 5'-nucleotidase |
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| UniProt accession | P49902 |
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| Gene | NT5C2 |
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| Organism | Homo sapiens |
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| Length | 561 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (276)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 48 · score 0.70
- hereditary spastic paraplegia 45 · score 0.65
- Autosomal recessive spastic paraplegia type 45 · score 0.46
- Intellectual disability · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- lymphoid neoplasm · score 0.37
- bile duct carcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- T-cell acute lymphoblastic leukemia · score 0.37
- B-cell acute lymphoblastic leukemia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49902-F1 | alphafold | PREDICTED | 88.87 | — |
Amino-acid sequence (561 residues)
MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS CETGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDG KLPLLLSRMK EVGKVFLATN SDYKYTDKIM TYLFDFPHGP KPGSSHRPWQ SYFDLILVDA RKPLFFGEGT VLRQVDTKTG KLKIGTYTGP LQHGIVYSGG SSDTICDLLG AKGKDILYIG DHIFGDILKS KKRQGWRTFL VIPELAQELH VWTDKSSLFE ELQSLDIFLA ELYKHLDSSS NERPDISSIQ RRIKKVTHDM DMCYGMMGSL FRSGSRQTLF ASQVMRYADL YAASFINLLY YPFSYLFRAA HVLMPHESTV EHTHVDINEM ESPLATRNRT SVDFKDTDYK RHQLTRSISE IKPPNLFPLA PQEITHCHDE DDDEEEEEEE E
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