About 5-formyltetrahydrofolate cyclo-ligase
5-formyltetrahydrofolate cyclo-ligase (MTHFS) is a protein
from Homo sapiens identified by UniProt accession
P49914, 203 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | 5-formyltetrahydrofolate cyclo-ligase |
|---|
| UniProt accession | P49914 |
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| Gene | MTHFS |
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| Organism | Homo sapiens |
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| Length | 203 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination · score 0.69
- blood protein measurement · score 0.39
- neurodegenerative disease · score 0.36
- eosinophil count · score 0.29
- Alzheimer disease · score 0.29
- Parkinson disease · score 0.29
- multiple sclerosis · score 0.29
- lysosomal storage disease · score 0.29
- eosinophil percentage of leukocytes · score 0.26
- monocyte percentage of leukocytes · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49914-F1 | alphafold | PREDICTED | 95.08 | — |
Amino-acid sequence (203 residues)
MAAAAVSSAK RSLRGELKQR LRAMSAEERL RQSRVLSQKV IAHSEYQKSK RISIFLSMQD EIETEEIIKD IFQRGKICFI PRYRFQSNHM DMVRIESPEE ISLLPKTSWN IPQPGEGDVR EEALSTGGLD LIFMPGLGFD KHGNRLGRGK GYYDAYLKRC LQHQEVKPYT LALAFKEQIC LQVPVNENDM KVDEVLYEDS STA
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