About GMP synthase [glutamine-hydrolyzing]
GMP synthase [glutamine-hydrolyzing] (GMPS) is a protein
from Homo sapiens identified by UniProt accession
P49915, 693 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | GMP synthase [glutamine-hydrolyzing] |
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| UniProt accession | P49915 |
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| Gene | GMPS |
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| Organism | Homo sapiens |
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| Length | 693 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (142)
Diseases linked to this target (Open Targets).
- acute graft vs. host disease · score 0.37
- rheumatoid arthritis · score 0.28
- lupus nephritis · score 0.26
- nephrotic syndrome · score 0.26
- rhabdomyosarcoma · score 0.25
- exercise test · score 0.24
- hepatocellular carcinoma · score 0.23
- pancreatic carcinoma · score 0.22
- esophageal squamous cell carcinoma · score 0.20
- esophageal carcinoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49915-F1 | alphafold | PREDICTED | 86.76 | — |
Amino-acid sequence (693 residues)
MALCNGDSKL ENAGGDLKDG HHHYEGAVVI LDAGAQYGKV IDRRVRELFV QSEIFPLETP AFAIKEQGFR AIIISGGPNS VYAEDAPWFD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK KSVREDGVFN ISVDNTCSLF RGLQKEEVVL LTHGDSVDKV ADGFKVVARS GNIVAGIANE SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTELIRK LREEGKVIEP LKDFHKDEVR ILGRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSVVIRTF ITSDFMTGIP ATPGNEIPVE VVLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE
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