Cyclin-dependent kinase inhibitor 1C (CDKN1C)

About Cyclin-dependent kinase inhibitor 1C

Cyclin-dependent kinase inhibitor 1C (CDKN1C) is a protein from Homo sapiens identified by UniProt accession P49918, 316 residues long. MolForge cross-references it against 0 known binders and 548 disease associations.

Target properties

Protein name	Cyclin-dependent kinase inhibitor 1C
UniProt accession	P49918
Gene	CDKN1C
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (548)

Diseases linked to this target (Open Targets).

Beckwith-Wiedemann syndrome · score 0.84
IMAGe syndrome · score 0.81
neurodegenerative disease · score 0.58
multiple sclerosis · score 0.52
Parkinson disease · score 0.52
lysosomal storage disease · score 0.52
Alzheimer disease · score 0.52
genetic disorder · score 0.45
isolated hemihyperplasia · score 0.38
Silver-Russell syndrome due to a point mutation · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49918-F1	alphafold	PREDICTED	62.75	—

Amino-acid sequence (316 residues)

MSDASLRSTS TMERLVARGT FPVLVRTSAC RSLFGPVDHE ELSRELQARL AELNAEDQNR WDYDFQQDMP LRGPGRLQWT EVDSDSVPAF YRETVQVGRC RLLLAPRPVA VAVAVSPPLE PAAESLDGLE EAPEQLPSVP VPAPASTPPP VPVLAPAPAP APAPVAAPVA APVAVAVLAP APAPAPAPAP APAPVAAPAP APAPAPAPAP APAPAPDAAP QESAEQGANQ GQRGQEPLAD QLHSGISGRP AAGTAAASAN GAAIKKLSGP LISDFFAKRK RSAPEKSSGD VPAPCPSPSA APGVGSVEQT PRKRLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards