About Ectonucleoside triphosphate diphosphohydrolase 1
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) is a protein
from Homo sapiens identified by UniProt accession
P49961, 510 residues long.
MolForge cross-references it against 0 known binders and
523 disease associations.
Target properties
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 1 |
|---|
| UniProt accession | P49961 |
|---|
| Gene | ENTPD1 |
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| Organism | Homo sapiens |
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| Length | 510 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (523)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 64 · score 0.75
- hereditary spastic paraplegia 64 · score 0.62
- blood protein measurement · score 0.37
- complex hereditary spastic paraplegia · score 0.37
- lymphocyte count · score 0.36
- platelet count · score 0.35
- electrocardiography · score 0.33
- protein measurement · score 0.30
- platelet component distribution width · score 0.21
- platelet crit · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49961-F1 | alphafold | PREDICTED | 90.99 | — |
Amino-acid sequence (510 residues)
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV
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