Type-2 angiotensin II receptor (AGTR2)

About Type-2 angiotensin II receptor

Type-2 angiotensin II receptor (AGTR2) is a protein from Homo sapiens identified by UniProt accession P50052, 363 residues long. MolForge cross-references it against 0 known binders and 378 disease associations.

Target properties

Protein name	Type-2 angiotensin II receptor
UniProt accession	P50052
Gene	AGTR2
Organism	Homo sapiens
Length	363 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (378)

Diseases linked to this target (Open Targets).

X-linked non-syndromic intellectual disability · score 0.37
glioblastoma multiforme · score 0.26
ovarian cancer · score 0.25
Inguinal hernia · score 0.25
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.16
neuroinflammatory disorder · score 0.16
low grade glioma · score 0.14
postherpetic neuralgia · score 0.09
neoplasm · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50052-F1	alphafold	PREDICTED	81.99	—

Amino-acid sequence (363 residues)

MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET FVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards