About Ketohexokinase
Ketohexokinase (KHK) is a protein
from Homo sapiens identified by UniProt accession
P50053, 298 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Ketohexokinase |
|---|
| UniProt accession | P50053 |
|---|
| Gene | KHK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 298 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- essential fructosuria · score 0.66
- Disorder of carbohydrate metabolism · score 0.37
- risk-taking behaviour · score 0.21
- leukocyte count · score 0.19
- cortical surface area measurement · score 0.18
- neutrophil count · score 0.16
- lymphocyte percentage of leukocytes · score 0.16
- brain measurement · score 0.13
- neuroimaging measurement · score 0.09
- mathematical ability · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50053-F1 | alphafold | PREDICTED | 97.31 | — |
Amino-acid sequence (298 residues)
MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM GSMAPGHVAD FLVADFRRRG VDVSQVAWQS KGDTPSSCCI INNSNGNRTI VLHDTSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV
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