Histamine N-methyltransferase (HNMT)

About Histamine N-methyltransferase

Histamine N-methyltransferase (HNMT) is a protein from Homo sapiens identified by UniProt accession P50135, 292 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.

Target properties

Protein name	Histamine N-methyltransferase
UniProt accession	P50135
Gene	HNMT
Organism	Homo sapiens
Length	292 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (165)

Diseases linked to this target (Open Targets).

autosomal recessive non-syndromic intellectual disability · score 0.54
mathematical ability · score 0.27
smoking initiation · score 0.12
cutaneous melanoma · score 0.10
gut microbiome measurement · score 0.10
systolic blood pressure · score 0.09
non-small cell lung carcinoma · score 0.08
diet measurement · score 0.06
alcohol use disorder measurement · score 0.06
attention deficit hyperactivity disorder · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50135-F1	alphafold	PREDICTED	95.82	—

Amino-acid sequence (292 residues)

MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards