Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)

About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4) is a protein from Homo sapiens identified by UniProt accession P50150, 75 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Disease associations (78)

Diseases linked to this target (Open Targets).

• neurodegenerative disease · score 0.45
• Parkinson disease · score 0.35
• Alzheimer disease · score 0.35
• multiple sclerosis · score 0.35
• lysosomal storage disease · score 0.35
• adolescent idiopathic scoliosis · score 0.30
• breast adenocarcinoma · score 0.28
• endometrial cancer · score 0.28
• chronic myelogenous leukemia · score 0.25
• lung adenocarcinoma · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (75 residues)

External references