Motor neuron and pancreas homeobox protein 1 (MNX1)

About Motor neuron and pancreas homeobox protein 1

Motor neuron and pancreas homeobox protein 1 (MNX1) is a protein from Homo sapiens identified by UniProt accession P50219, 401 residues long. MolForge cross-references it against 0 known binders and 230 disease associations.

Target properties

Protein name	Motor neuron and pancreas homeobox protein 1
UniProt accession	P50219
Gene	MNX1
Organism	Homo sapiens
Length	401 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (230)

Diseases linked to this target (Open Targets).

Currarino triad · score 0.80
permanent neonatal diabetes mellitus · score 0.37
neonatal diabetes mellitus · score 0.37
anorectal malformation · score 0.37
protein measurement · score 0.21
non-small cell lung carcinoma · score 0.21
hepatocellular carcinoma · score 0.21
urinary bladder carcinoma · score 0.21
lung adenocarcinoma · score 0.20
colon adenocarcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50219-F1	alphafold	PREDICTED	57.12	—

Amino-acid sequence (401 residues)

MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards