Homeobox protein MOX-1 (MEOX1)

About Homeobox protein MOX-1

Homeobox protein MOX-1 (MEOX1) is a protein from Homo sapiens identified by UniProt accession P50221, 254 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Homeobox protein MOX-1
UniProt accession	P50221
Gene	MEOX1
Organism	Homo sapiens
Length	254 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

Klippel-Feil syndrome 2, autosomal recessive · score 0.69
Cervical C2/C3 vertebral fusion · score 0.56
isolated Klippel-Feil syndrome · score 0.38
heel bone mineral density · score 0.25
bone fracture · score 0.20
genetic disorder · score 0.19
apolipoprotein A 1 measurement · score 0.18
triglyceride measurement · score 0.18
high density lipoprotein cholesterol measurement · score 0.18
Drugs affecting bone structure and mineralization use measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50221-F1	alphafold	PREDICTED	62.55	—

Amino-acid sequence (254 residues)

MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHQKPD FLATATAAYP DFSASCLAAT PHSLPQEEHI FTEQHPAFPQ SPNWHFPVSD ARRRPNSGPA GGSKEMGTSS LGLVDTTGGP GDDYGVLGST ANETEKKSSR RRKESSDNQE NRGKPEGSSK ARKERTAFTK EQLRELEAEF AHHNYLTRLR RYEIAVNLDL SERQVKVWFQ NRRMKWKRVK GGQPISPNGQ DPEDGDSTAS PSSE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards