About Protoporphyrinogen oxidase
Protoporphyrinogen oxidase (PPOX) is a protein
from Homo sapiens identified by UniProt accession
P50336, 477 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | Protoporphyrinogen oxidase |
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| UniProt accession | P50336 |
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| Gene | PPOX |
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| Organism | Homo sapiens |
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| Length | 477 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (123)
Diseases linked to this target (Open Targets).
- variegate porphyria · score 0.81
- Porphyria variegata · score 0.77
- neurodegenerative disease · score 0.52
- Abnormal blistering of the skin · score 0.42
- Sensory neuropathy · score 0.37
- Abnormal urinary color · score 0.34
- migraine disorder · score 0.34
- Constipation · score 0.34
- Porphyrinuria · score 0.33
- Abdominal colic · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50336-F1 | alphafold | PREDICTED | 95.28 | — |
Amino-acid sequence (477 residues)
MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVESSERLG GWIRSVRGPN GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY VGGALHALPT GLRGLLRPSP PFSKPLFWAG LRELTKPRGK EPDETVHSFA QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG LLLGAGRTPQ PDSALIRQAL AERWSQWSLR GGLEMLPQAL ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD HVISAIPASV LSELLPAEAA PLARALSAIT AVSVAVVNLQ YQGAHLPVQG FGHLVPSSED PGVLGIVYDS VAFPEQDGSP PGLRVTVMLG GSWLQTLEAS GCVLSQELFQ QRAQEAAATQ LGLKEMPSHC LVHLHKNCIP QYTLGHWQKL ESARQFLTAH RLPLTLAGAS YEGVAVNDCI ESGRQAAVSV LGTEPNS
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