Neuropeptide Y receptor type 4 (NPY4R)

About Neuropeptide Y receptor type 4

Neuropeptide Y receptor type 4 (NPY4R) is a protein from Homo sapiens identified by UniProt accession P50391, 375 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Neuropeptide Y receptor type 4
UniProt accession	P50391
Gene	NPY4R
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.26
ovarian cancer · score 0.25
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.16
low grade glioma · score 0.14
neuroblastoma · score 0.11
obesity · score 0.07
mean corpuscular volume · score 0.05
mean corpuscular hemoglobin · score 0.05
erythrocyte count · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50391-F1	alphafold	PREDICTED	80.31	—

Amino-acid sequence (375 residues)

MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI ETVVGVLGNL CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV YTIMDYWIFG ETLCKMSAFI QCMSVTVSIL SLVLVALERH QLIINPTGWK PSISQAYLGI VLIWVIACVL SLPFLANSIL ENVFHKNHSK ALEFLADKVV CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRC LQRQGRVFHK GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE HLPLSTVHTE VSKGSLRLSG RSNPI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards