Rab GDP dissociation inhibitor beta (GDI2)

About Rab GDP dissociation inhibitor beta

Rab GDP dissociation inhibitor beta (GDI2) is a protein from Homo sapiens identified by UniProt accession P50395, 445 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	Rab GDP dissociation inhibitor beta
UniProt accession	P50395
Gene	GDI2
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
blood protein measurement · score 0.34
cutaneous melanoma · score 0.27
nevus count · score 0.27
monocyte count · score 0.22
drug use measurement · score 0.19
body height · score 0.16
age at menopause · score 0.16
monocyte percentage of leukocytes · score 0.14
systemic lupus erythematosus · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50395-F1	alphafold	PREDICTED	93.79	—

Amino-acid sequence (445 residues)

MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE DLYKRFKIPG SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVTEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI SRTYDATTHF ETTCDDIKNI YKRMTGSEFD FEEMKRKKND IYGED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards