About Emerin
Emerin (EMD) is a protein
from Homo sapiens identified by UniProt accession
P50402, 254 residues long.
MolForge cross-references it against 0 known binders and
269 disease associations.
Target properties
| Protein name | Emerin |
|---|
| UniProt accession | P50402 |
|---|
| Gene | EMD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 254 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (269)
Diseases linked to this target (Open Targets).
- X-linked Emery-Dreifuss muscular dystrophy · score 0.75
- Abnormality of the cardiovascular system · score 0.50
- Emery-Dreifuss muscular dystrophy · score 0.47
- neuromuscular disease · score 0.46
- heart conduction disease · score 0.37
- myopathy · score 0.35
- neurodegenerative disease · score 0.34
- Flexion contracture · score 0.34
- Failure to thrive · score 0.34
- X-linked myopathy with postural muscle atrophy · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50402-F1 | alphafold | PREDICTED | 60.25 | — |
Amino-acid sequence (254 residues)
MDNYADLSDT ELTTLLRRYN IPHGPVVGST RRLYEKKIFE YETQRRRLSP PSSSAASSYS FSDLNSTRGD ADMYDLPKKE DALLYQSKGY NDDYYEESYF TTRTYGEPES AGPSRAVRQS VTSFPDADAF HHQVHDDDLL SSSEEECKDR ERPMYGRDSA YQSITHYRPV SASRSSLDLS YYPTSSSTSF MSSSSSSSSW LTRRAIRPEN RAPGAGLGQD RQVPLWGQLL LFLVFVIVLF FIYHFMQAEE GNPF
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