Serpin B8 (SERPINB8)

About Serpin B8

Serpin B8 (SERPINB8) is a protein from Homo sapiens identified by UniProt accession P50452, 374 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Serpin B8
UniProt accession	P50452
Gene	SERPINB8
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

peeling skin syndrome · score 0.61
ichthyosis · score 0.37
exfoliative ichthyosis · score 0.37
Erythema · score 0.37
peeling skin syndrome type A · score 0.37
Palmoplantar hyperkeratosis · score 0.37
blood protein measurement · score 0.33
atopic eczema · score 0.14
trans fatty acid measurement · score 0.06
trans/trans-18:2 fatty acid measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50452-F1	alphafold	PREDICTED	91.07	—

Amino-acid sequence (374 residues)

MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST AAQMSQALCL YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF LPDFKEYCQK FYQAELEELS FAEDTEECRK HINDWVAEKT EGKISEVLDA GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV VEKALTYEKF KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD HPFLFFIRHH KTNCILFCGR FSSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards