Serpin H1 (SERPINH1)

About Serpin H1

Serpin H1 (SERPINH1) is a protein from Homo sapiens identified by UniProt accession P50454, 418 residues long. MolForge cross-references it against 0 known binders and 325 disease associations.

Target properties

Protein name	Serpin H1
UniProt accession	P50454
Gene	SERPINH1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (325)

Diseases linked to this target (Open Targets).

osteogenesis imperfecta type 10 · score 0.71
body height · score 0.68
preterm premature rupture of the membranes · score 0.55
Skeletal dysplasia · score 0.46
osteogenesis imperfecta type 3 · score 0.46
neurodegenerative disease · score 0.43
BMI-adjusted waist circumference · score 0.41
coronary artery disease · score 0.38
BMI-adjusted hip circumference · score 0.38
appendicular lean mass · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50454-F1	alphafold	PREDICTED	91.14	—

Amino-acid sequence (418 residues)

MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards