LIM/homeobox protein Lhx2 (LHX2)

About LIM/homeobox protein Lhx2

LIM/homeobox protein Lhx2 (LHX2) is a protein from Homo sapiens identified by UniProt accession P50458, 406 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	LIM/homeobox protein Lhx2
UniProt accession	P50458
Gene	LHX2
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
hair color · score 0.46
Neurodevelopmental disorder · score 0.44
hair colour measurement · score 0.34
waist circumference · score 0.32
mathematical ability · score 0.31
balding measurement · score 0.27
unipolar depression · score 0.26
adolescent idiopathic scoliosis · score 0.23
non-small cell lung carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50458-F1	alphafold	PREDICTED	65.54	—

Amino-acid sequence (406 residues)

MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT TLTNLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards