PDZ and LIM domain protein 4 (PDLIM4)

About PDZ and LIM domain protein 4

PDZ and LIM domain protein 4 (PDLIM4) is a protein from Homo sapiens identified by UniProt accession P50479, 330 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	PDZ and LIM domain protein 4
UniProt accession	P50479
Gene	PDLIM4
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
neutrophil count · score 0.41
body height · score 0.36
leukocyte count · score 0.34
Red cell distribution width · score 0.30
lymphocyte count · score 0.26
blood protein measurement · score 0.25
urate measurement · score 0.24
blood metabolite measurement · score 0.20
brain measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50479-F1	alphafold	PREDICTED	70.17	—

Amino-acid sequence (330 residues)

MPHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPEGRSWPS APDDSKAQAH RIHIDPEIQD GSPTTSRRPS GTGTGPEDGR PSLGSPYGQP PRFPVPHNGS SEATLPAQMS TLHVSPPPSA DPARGLPRSR DCRVDLGSEV YRMLREPAEP VAAEPKQSGS FRYLQGMLEA GEGGDWPGPG GPRNLKPTAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCESHAKARV KPPEGYDVVA VYPNAKVELV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards