About Peroxisomal targeting signal 1 receptor
Peroxisomal targeting signal 1 receptor (PEX5) is a protein
from Homo sapiens identified by UniProt accession
P50542, 639 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Peroxisomal targeting signal 1 receptor |
|---|
| UniProt accession | P50542 |
|---|
| Gene | PEX5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 639 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- peroxisome biogenesis disorder 2A (Zellweger) · score 0.75
- Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.75
- rhizomelic chondrodysplasia punctata type 5 · score 0.69
- Zellweger syndrome · score 0.63
- peroxisome biogenesis disorder · score 0.44
- peroxisome biogenesis disorder type 3B · score 0.37
- peroxisome biogenesis disorder, complementation group 7 · score 0.37
- rhizomelic chondrodysplasia punctata · score 0.34
- neurodegenerative disease · score 0.34
- peroxisome biogenesis disorder due to PEX5 defect · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50542-F1 | alphafold | PREDICTED | 69.85 | — |
Amino-acid sequence (639 residues)
MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA SKPLGVASED ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VTQDYNETDW SQEFISEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGTA TDRWYDEYHP EEDLQHTASD FVAKVDDPKL ANSEFLKFVR QIGEGQVSLE SGAGSGRAQA EQWAAEFIQQ QGTSDAWVDQ FTRPVNTSAL DMEFERAKSA IESDVDFWDK LQAELEEMAK RDAEAHPWLS DYDDLTSATY DKGYQFEEEN PLRDHPQPFE EGLRRLQEGD LPNAVLLFEA AVQQDPKHME AWQYLGTTQA ENEQELLAIS ALRRCLELKP DNQTALMALA VSFTNESLQR QACETLRDWL RYTPAYAHLV TPAEEGAGGA GLGPSKRILG SLLSDSLFLE VKELFLAAVR LDPTSIDPDV QCGLGVLFNL SGEYDKAVDC FTAALSVRPN DYLLWNKLGA TLANGNQSEE AVAAYRRALE LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS ENIWSTLRLA LSMLGQSDAY GAADARDLST LLTMFGLPQ
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