About ETS domain-containing transcription factor ERF
ETS domain-containing transcription factor ERF (ERF) is a protein
from Homo sapiens identified by UniProt accession
P50548, 548 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | ETS domain-containing transcription factor ERF |
|---|
| UniProt accession | P50548 |
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| Gene | ERF |
|---|
| Organism | Homo sapiens |
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| Length | 548 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- craniosynostosis 4 · score 0.75
- Chitayat syndrome · score 0.69
- TWIST1-related craniosynostosis · score 0.56
- Lambdoidal craniosynostosis · score 0.55
- isolated oxycephaly · score 0.54
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.52
- isolated scaphocephaly · score 0.38
- Crouzon syndrome · score 0.37
- Macrocephaly · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50548-F1 | alphafold | PREDICTED | 53.76 | — |
Amino-acid sequence (548 residues)
MKTPADTGFA FPDWAYKPES SPGSRQIQLW HFILELLRKE EYQGVIAWQG DYGEFVIKDP DEVARLWGVR KCKPQMNYDK LSRALRYYYN KRILHKTKGK RFTYKFNFNK LVLVNYPFID VGLAGGAVPQ SAPPVPSGGS HFRFPPSTPS EVLSPTEDPR SPPACSSSSS SLFSAVVARR LGRGSVSDCS DGTSELEEPL GEDPRARPPG PPDLGAFRGP PLARLPHDPG VFRVYPRPRG GPEPLSPFPV SPLAGPGSLL PPQLSPALPM TPTHLAYTPS PTLSPMYPSG GGGPSGSGGG SHFSFSPEDM KRYLQAHTQS VYNYHLSPRA FLHYPGLVVP QPQRPDKCPL PPMAPETPPV PSSASSSSSS SSSPFKFKLQ PPPLGRRQRA AGEKAVAGAD KSGGSAGGLA EGAGALAPPP PPPQIKVEPI SEGESEEVEV TDISDEDEED GEVFKTPRAP PAPPKPEPGE APGASQCMPL KLRFKRRWSE DCRLEGGGGP AGGFEDEGED KKVRGEGPGE AGGPLTPRRV SSDLQHATAQ LSLEHRDS
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