About Achaete-scute homolog 1
Achaete-scute homolog 1 (ASCL1) is a protein
from Homo sapiens identified by UniProt accession
P50553, 236 residues long.
MolForge cross-references it against 0 known binders and
244 disease associations.
Target properties
| Protein name | Achaete-scute homolog 1 |
|---|
| UniProt accession | P50553 |
|---|
| Gene | ASCL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 236 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (244)
Diseases linked to this target (Open Targets).
- Haddad syndrome · score 0.40
- amino acid measurement · score 0.39
- phenylalanine measurement · score 0.38
- sex hormone-binding globulin measurement · score 0.36
- C-reactive protein measurement · score 0.36
- apolipoprotein A 1 measurement · score 0.31
- testosterone measurement · score 0.30
- triglyceride measurement · score 0.29
- self reported educational attainment · score 0.29
- serum gamma-glutamyl transferase measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50553-F1 | alphafold | PREDICTED | 67.36 | — |
Amino-acid sequence (236 residues)
MESSAKMESG GAGQQPQPQP QQPFLPPAAC FFATAAAAAA AAAAAAAQSA QQQQQQQQQQ QQAPQLRPAA DGQPSGGGHK SAPKQVKRQR SSSPELMRCK RRLNFSGFGY SLPQQQPAAV ARRNERERNR VKLVNLGFAT LREHVPNGAA NKKMSKVETL RSAVEYIRAL QQLLDEHDAV SAAFQAGVLS PTISPNYSND LNSMAGSPVS SYSSDEGSYD PLSPEEQELL DFTNWF
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