About Dynamin-2
Dynamin-2 (DNM2) is a protein
from Homo sapiens identified by UniProt accession
P50570, 870 residues long.
MolForge cross-references it against 0 known binders and
1,002 disease associations.
Target properties
| Protein name | Dynamin-2 |
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| UniProt accession | P50570 |
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| Gene | DNM2 |
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| Organism | Homo sapiens |
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| Length | 870 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1002)
Diseases linked to this target (Open Targets).
- autosomal dominant centronuclear myopathy · score 0.84
- Charcot-Marie-Tooth disease dominant intermediate B · score 0.80
- Autosomal dominant intermediate Charcot-Marie-Tooth disease type B · score 0.79
- fetal akinesia-cerebral and retinal hemorrhage syndrome · score 0.73
- centronuclear myopathy · score 0.69
- Charcot-Marie-Tooth disease · score 0.59
- autosomal dominant Charcot-Marie-Tooth disease type 2M · score 0.55
- intermediate Charcot-Marie-Tooth disease · score 0.49
- neurodegenerative disease · score 0.44
- X-linked myotubular myopathy · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50570-F1 | alphafold | PREDICTED | 77.58 | — |
Amino-acid sequence (870 residues)
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPSRR PPAAPSRPTI IRPAEPSLLD
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