About Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (NUDT2) is a protein
from Homo sapiens identified by UniProt accession
P50583, 147 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] |
|---|
| UniProt accession | P50583 |
|---|
| Gene | NUDT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 147 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with or without peripheral neuropathy · score 0.58
- Intellectual disability · score 0.50
- Hypotonia · score 0.42
- polyneuropathy · score 0.37
- Global developmental delay · score 0.37
- complex neurodevelopmental disorder · score 0.27
- breast adenocarcinoma · score 0.18
- Red cell distribution width · score 0.15
- diet measurement · score 0.12
- melanoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50583-F1 | alphafold | PREDICTED | 94.96 | — |
Amino-acid sequence (147 residues)
MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED DLETALRETQ EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD YDVEIRLSHE HQAYRWLGLE EACQLAQFKE MKAALQEGHQ FLCSIEA
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