Tubby protein homolog (TUB)

About Tubby protein homolog

Tubby protein homolog (TUB) is a protein from Homo sapiens identified by UniProt accession P50607, 506 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.

Target properties

Protein name	Tubby protein homolog
UniProt accession	P50607
Gene	TUB
Organism	Homo sapiens
Length	506 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (174)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.58
age-related hearing impairment · score 0.42
neurodegenerative disease · score 0.39
creatinine measurement · score 0.34
autism spectrum disorder · score 0.33
diet measurement · score 0.31
hearing loss · score 0.31
appendicitis · score 0.31
Retinal dystrophy · score 0.27
metabolite measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50607-F1	alphafold	PREDICTED	69.14	—

Amino-acid sequence (506 residues)

MTSKPHSDWI PYSVLDDEGR NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA NADGRPRSRR ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQLGATR PTAPASAKRT KAAATAGGQG GAARKEKKGK HKGTSGPAAL AEDKSEAQGP VQILTVGQSD HAQDAGETAA GGGERPSGQD LRATMQRKGI SSSMSFDEDE EDEEENSSSS SQLNSNTRPS SATSRKSVRE AASAPSPTAP EQPVDVEVQD LEEFALRPAP QGITIKCRIT RDKKGMDRGM YPTYFLHLDR EDGKKVFLLA GRKRKKSKTS NYLISVDPTD LSRGGDSYIG KLRSNLMGTK FTVYDNGVNP QKASSSTLES GTLRQELAAV CYETNVLGFK GPRKMSVIVP GMNMVHERVS IRPRNEHETL LARWQNKNTE SIIELQNKTP VWNDDTQSYV LNFHGRVTQA SVKNFQIIHG NDPDYIVMQF GRVAEDVFTM DYNYPLCALQ AFAIALSSFD SKLACE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards