Cyclin-dependent kinase 7 (CDK7)

About Cyclin-dependent kinase 7

Cyclin-dependent kinase 7 (CDK7) is a protein from Homo sapiens identified by UniProt accession P50613, 346 residues long. MolForge cross-references it against 0 known binders and 187 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 7
UniProt accession	P50613
Gene	CDK7
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (187)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
neurodegenerative disease · score 0.53
glioblastoma multiforme · score 0.30
endometrial cancer · score 0.29
breast adenocarcinoma · score 0.27
neuroinflammatory disorder · score 0.21
lung adenocarcinoma · score 0.20
squamous cell lung carcinoma · score 0.19
esophageal cancer · score 0.18
urinary bladder cancer · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50613-F1	alphafold	PREDICTED	82.02	—

Amino-acid sequence (346 residues)

MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards