Cyclin-dependent kinase 9 (CDK9)

About Cyclin-dependent kinase 9

Cyclin-dependent kinase 9 (CDK9) is a protein from Homo sapiens identified by UniProt accession P50750, 372 residues long. MolForge cross-references it against 0 known binders and 296 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 9
UniProt accession	P50750
Gene	CDK9
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (296)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
Global developmental delay · score 0.42
choanal atresia · score 0.42
Abnormality of vision · score 0.42
Preauricular skin tag · score 0.42
Abnormality of the ear · score 0.42
disease of genitourinary system · score 0.42
Developmental cataract · score 0.42
Hearing impairment · score 0.42
Intellectual disability · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50750-F1	alphafold	PREDICTED	86.82	—

Amino-acid sequence (372 residues)

MAKQYDSVEC PFCDEVSKYE KLAKIGQGTF GEVFKARHRK TGQKVALKKV LMENEKEGFP ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY LVFDFCEHDL AGLLSNVLVK FTLSEIKRVM QMLLNGLYYI HRNKILHRDM KAANVLITRD GVLKLADFGL ARAFSLAKNS QPNRYTNRVV TLWYRPPELL LGERDYGPPI DLWGAGCIMA EMWTRSPIMQ GNTEQHQLAL ISQLCGSITP EVWPNVDNYE LYEKLELVKG QKRKVKDRLK AYVRDPYALD LIDKLLVLDP AQRIDSDDAL NHDFFWSDPM PSDLKGMLST HLTSMFEYLA PPRRKGSQIT QQSTNQSRNP ATTNQTEFER VF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards