E3 ubiquitin-protein ligase RNF144A (RNF144A)

About E3 ubiquitin-protein ligase RNF144A

E3 ubiquitin-protein ligase RNF144A (RNF144A) is a protein from Homo sapiens identified by UniProt accession P50876, 292 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF144A
UniProt accession	P50876
Gene	RNF144A
Organism	Homo sapiens
Length	292 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
hemoglobin measurement · score 0.40
blood phosphate measurement · score 0.39
hematocrit · score 0.37
brain aneurysm · score 0.31
lymphocyte count · score 0.25
lymphocyte percentage of leukocytes · score 0.21
balding measurement · score 0.20
hair shape measurement · score 0.19
self reported educational attainment · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50876-F1	alphafold	PREDICTED	81.20	—

Amino-acid sequence (292 residues)

MTTTRYRPTW DLALDPLVSC KLCLGEYPVE QMTTIAQCQC IFCTLCLKQY VELLIKEGLE TAISCPDAAC PKQGHLQENE IECMVAAEIM QRYKKLQFER EVLFDPCRTW CPASTCQAVC QLQDVGLQTP QPVQCKACRM EFCSTCKASW HPGQGCPETM PITFLPGETS AAFKMEEDDA PIKRCPKCKV YIERDEGCAQ MMCKNCKHAF CWYCLESLDD DFLLIHYDKG PCRNKLGHSR ASVIWHRTQV VGIFAGFGLL LLVASPFLLL ATPFVLCCKC KCSKGDDDPL PT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards